ADAM17 Protein

A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

Also Known As:

ADAM-17; ADAM-17 Protein; CD156b Antigen; Disintegrin and Metalloproteinase Domain-Containing Protein 17; TACA (Enzyme); TACE (Enzyme); TNF-alpha Convertase; TNF-alpha Converting Enzyme; Tumor Necrosis Factor Alpha Convertase; Tumor Necrosis Factor-alpha Convertase; Tumor Necrosis Factor-alpha Converting Enzyme; ADAM 17 Protein; Antigen, CD156b; Convertase, TNF-alpha; Disintegrin and Metalloproteinase Domain Containing Protein 17; TNF alpha Convertase; TNF alpha Converting Enzyme; Tumor Necrosis Factor alpha Converting Enzyme

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        ADAM Proteins: 24
        ADAM17 Protein: 202
Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - ADAM Proteins: 24
      - ADAM17 Protein: 202
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - ADAM Proteins: 24
      - ADAM17 Protein: 202

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Disease

Drug/Important Bio-Agent (IBA)